ABSTRACT
HIDEAKI KAWAGUCHI* Department of Pathophysiological Science and Laboratory Medicine, Hokkaido University Graduate School of Medicine, Kita-5, Nishi-7, Kita-Ku, Sapporo 060-8638, Japan
Abstract-In the hearts of spontaneously hypertensive rats, mRNA of the renin-angiotensin system (renin, angiotensinogen, and angiotensin converting enzyme) was expressed. Level of angiotensinogen and renin mRNA expressed in ventricles, and angiotensinogen mRNA expressed in fibroblasts from SHR were higher than those from WKY. ACE mRNA was also more strongly expressed in the ventricles and fibroblasts from SHR compared with those of WKY.
