ABSTRACT
Abstract-Arterial pressure and renal pelvic pressure have been shown to modulate renal functions. We examined the effect of hemorrhage on renal pelvic motility in urethane-chloralose anesthetized rats. Renal pelvic pressure showed rhythmic oscillations and hemorrhage increased the frequency of pelvic pressure oscillations. In adrenomedullectomized rats, hemorrhage did not increase the frequency of oscillation. The frequency of spontaneous contraction in isolated ring preparations of renal pelvis was increased concentration-dependently by phenylephrine, clonidine, adrenaline and noradrenaline. Isoproterenol decreased the frequency at concentration below 10 p,M. CGP-12177A, a ^3-agonist, was without effect. These results indicate that the increase of renal pelvic motility by hemorrhage in rats could be mediated by catecholamines released from the adrenal medulla.
