ABSTRACT
The identification of possible interferences is important to both specific and non-specific methods. In the case of specific methods there should not be any interferences if the method was properly developed. It is important that the method is able to detect the analyte after exposure to the cleaning environment. Studies should be conducted to demonstrate that the analyte does not change after exposure to alkaline or acidic cleaners. This can be simply done by exposing the drug active to a dilution of the cleaning agent at the temperature that will be utilized during the cleaning process. This sample can then be analyzed to determine if the analyte can still be detected and quantitated. If this is not done the analyte may not be detected even though it is present in the sample. If the cleaning environment does change the nature of the analyte a new method would be required or modifications would have to be made to the existing method. When utilizing a non-specific method to measure a non-specific property, any compound that displays that property and is introduced into the sample will interfere. Possible sources of interferences could be from the environment, sampling technique, and/or people.
