ABSTRACT
Cancer is a disease characterized by the autonomous, aimless and excessive proliferation of cells, in which genetic abnormality is accumulated. The cells invade their surrounding tissues and metastasize to distant organs (expansion of cancer), leading to disturbance of normal homeostasis and, in turn, death of host human beings. Due to these DNA abnormalities the proteins are synthesized based on a fl awed blueprint, and either leave the mitogenic signal switched on or suppress cell death, resulting in cancer cell transformation. Therefore, cell signaling, especially that regulating proliferation, is intimately associated with oncogenesis-cancer cells possess a chaotic signal transduction system compared to the organized one in normal cells.
