ABSTRACT
Reactive oxygen species (ROS) have a few possible effects such as metabolic (participation in regulation of protein functions), damaging (oxidative damage to proteins, lipids and nucleic acids) and signal; the latter is reviewed in the article. Superoxide anion-radical 0~, hydroperoxide (H20 2) and nitroxide (NO) are capable to act as signal substances in the cell regulatory network, which determines a model of cell response to indignating exposure: proliferation rate, a direction of differentiation or a start of the apoptosis program. A role of ROS in this network is considered: significance of ROS contents in a cell; signal pathways triggered the programs of cell response on exposures; links of regulatory networks conditioned of ROS contents in the cell; ROS reactions with network components which influences its functioning. A significance of the ROS-bound segment of network that realizes regulatory signals ofthe damage in development of radiobiological effect is estimated. The data obtained by the authors are submitted; the prospects of studying substances
(such as phenosane, etc) which can actively influence redox processes, as means of modification of radiation-induced genome instability and prevention of malignant transformation are considered.
