ABSTRACT
Figure I shows the dependence of amount of aberrant cells on irradiation dose in asynchronous populations of Chinese hamster and human melanoma cells. Dose-effect curves have similar pronounced non-linear character. Percentage of aberrant cells increases in the range 0-I 0 in human melanoma and 0-20 cGy in Chinese hamster cells (HRS region), then it decreases rapidly. Percentage of cells with aberrations in melanoma cells at the dose of 20 cGy is lower than in control, i.e. inverse negative relationship on dose takes place. Dose dependence becomes linear with dose increasing over 30-50 cGy (IR}, and the slope of the curve decreases significantly in comparison to initial one.
