ABSTRACT

High-throughput screening (HTS) incorporates a combination of modern robotics, data processing and control software, liquid handling devices, and sensitive detectors that allow effi cient and smooth processing of millions of biochemical, genetic, or pharmacological tests in a short time. It provides a rapid, cost-effective method to screen potential sources for novel molecules often used in drug development. Unlike conventional or manual screening procedures, HTS allows for the handling of a wide variety of input samples; each sample is stamped with its own set of data and tracking issues and produces new experimental results. Thus, HTS makes it possible to collect large amounts of experimental data related to observations about biological reactions to exposure to various chemical compounds.