Potent Anticancer Actions of Omega-3 Polyunsaturated Fatty Acids of Marine Nutraceuticals � � � � � � � � � � � � � � � � � � � � � �

Progression .............................................................................................206 15.4.1 Role of ω3-PUFAs on Genome Instability: Implications

for Epigenetic Regulation ............................................................206 15.4.1.1 DNA Methylation and ω3-PUFAs ...................................206 15.4.1.2 Chromatin Modulation and ω3-PUFAs ..........................207 15.4.1.3 miRs and ω3-PUFAs .......................................................208

15.4.2 Role of ω3-PUFAs in Cancer Cell Proliferation ..........................208 15.4.2.1 Cyclin-CDK Complex-Controlled Cell Cycle