ABSTRACT
While virtually unknown during this age of diets and bariatric surgery, the concept that chemosensory stimuli may mediate satiety has existed for decades at least. As opposed to allesthesia from secondary effects of ingestion (stretch receptors in stomach, change in insulin, or metabolic effect), chemosensory-mediated satiety occurs even before ingestion and absorption. This has been shown with both high-fat or high-carbohydrate liquid meals, which when infused directly into the stomach or into the small intestine had less appetite suppression effects than when provided orally (Cecil et al. 1998a,b); whereas when a chemosensory stimulus is sniffed or mandibulated without deglutination, satiety is produced (Chapelot and Louis-Sylvestre 2008).
