ABSTRACT
Oxidized phospholipids (OxPLs) have been identied as an active component in minimally modied low-density lipoproteins (LDLs), which is a proinammatory form of LDL generated by mild oxidation of lipoproteins in the presence of
Introduction ............................................................................................................ 195 Generation of OxPLs ............................................................................................. 196 Biological Activities of OxPLs Potentially Relevant to Inammation .................. 197
Induction of Inammatory Cell Adhesion Molecules and MonocyteEndothelial Interactions .................................................................................... 197 Induction of Inammatory Cytokines ............................................................... 198 Receptors Mediating Inammatory Action of OxPLs ...................................... 199 Inhibition of Phagocytosis .................................................................................200 Inhibition of Oxidative Burst ............................................................................200 Inhibition of TLR Activation by Bacterial Products .........................................200
Accumulation and Role of OxPLs in Inammatory Pathologies .......................... 201 Acute Inammation ........................................................................................... 201 Atherosclerosis ..................................................................................................202 Leprosy ..............................................................................................................202 Multiple Sclerosis..............................................................................................203 Age-Related Macular Degeneration ..................................................................203 Lung Injury........................................................................................................204 Chronic Exposure to Fine Particulate Matter ....................................................204
Summary: Potential Role of OxPLs in Inammatory Conditions .........................204 Biphasic Effects of OxPLs in LPS-Induced Proinammatory Reactions .........204 Dual Role of OxPLs in Inammation ...............................................................206
Abbreviations .........................................................................................................206 References ..............................................................................................................207
