ABSTRACT
Aluminum can readily cross the blood brain barrier after systemic administration and may use the same high affinity receptor ligand system that has been postulated for iron. Once in the brain, Al accumulates in various regions including the hippocampus where it can interfere with synaptic plasticity in a dose dependent manner. Application of different Al salts has generated neurofibrillary degeneration similar to that found with patients of dementia.2
