A ccelerated Protein Evolution U sing R ibosom e D isplay...................... ....... J u lie Dou th w a ite , L u tz J erm u tu s, R on a ld Ja ckso n

Ribosome display is a powerful selection technology for the identification o f proteins with desired functions and has wide applicability across biologies drug discovery and basic research. Ribosome display is based on polymerase chain reaction and cell-free translation technologies that combine to provide an entirely in vitro process for selection and directed evolu­ tion that is rapid and highly effective. Using ribosome display, human monocolonal therapeutic antibodies are efficiendy evolved for optimum affinity.