ABSTRACT
Although there were early sporadic attempts to use bone marrow for its thera peutic effect in anemia and leukemia by oral, intramuscular or even intravenous routes, the first detonation of a nuclear device on July 16,1945 provided the major stimulus for research in bone marrow transplantation. This research was initially heavily supported by various government agencies that had an interest in under standing the pathophysiology of ionizing radiation injury in man.
