ABSTRACT
The possible model of RIG-I activation is: 1. Binding of RNA ligand to CTD, and ATP to H-I and H-III 2. Conformational change in the helicase region (encircling structure) and its binding
to dsRNA 3. Conformational change (step 2) releases tandem CARDs
Further studies are still necessary to clarify the details of RLR activation.
