ABSTRACT
Inactivated virus vaccines have made a significant contribution to the control o f infectious disease during the 20th century and will surely remain an important feature o f vaccination strategies in the 21st century. Inactivated vaccines are currently widely available for polio myelitis, influenza, rabies, hepatitis A, tick-borne encephalitis (TBE) and Japanese encephalitis (JE), and several other products are available for limited, primarily military, use. Inactivated vaccines have been proposed for several other viruses, m ost notably H IV (see below), hantaviruses1'4 and dengue,5'7 but are not yet licensed. For comprehensive and up-to-date reviews concerning specific products, the reader is referred to the various chapters o f Plotkin and Orensteins definitive work on vaccines.8
