ABSTRACT
Fig. 28.1. (left) Effect o f the CGRPi receptor antagonist, CGRPs-37, on basal b lood flow o f the rabbit knee joint. The drug was ad m inistered as a bolus o f 0.1 m l applied to the surface o f the jo in t capsule. D ata are show n as m eans ± s.e.mean. (shown by vertical bars) expressed as voltage tha t corresponds to tis sue perfusion. CGRPg-37 had no effect at 0.01 nm ol (n=6) b u t p roduced significant vaso constriction on the articular b lood vessels at 0.1 n m o l (n= 7 ) an d 1 n m o l (n= 5 ). **= P<0.01; ***= PcO.OOl.
