ABSTRACT
Antithymocyte Delaying Onset o f A llograft Rejection Globulin (Atgam) • Fixed dose of 15 mg/kg for 14 days, then every other day for 14 days
for a total of 21 doses in 28 days • First dose should be administered within 24 hours before or after
transplantation
Treatment o f Rejection ___________________ *10-1 5 mg/kg/d IV for 8-14 days, then every other day up to 21 doses
Antithymocyte Treatment o f Rejection Globulin (rabbit) • 1.5 mg/kg/d for 7 to 14 days IV__________________________________
Muromonab-CD3 • 5 mg/d IV for 10 to 14 days_____________________________________
Basiliximab • 20 mg within 2 hours of transplantation surgery and repeated 4 days _____________________after transplantation____________________________________________
Daclizumab • 1 mg/kg/dose for 5 doses. The first dose within 24 hours of trans_____________________plantation, then at intervals of 14 days for 4 doses__________________
Alemtuzumab • 30 mg intravenously on the day of transplantation surgery and another _____________________30 mg may be given on post-operation day 1_______________________
Rituximab • 375 mg/m2 (with a maximum dose of 750 mg) intravenously, may _____________________repeat one more time 2 weeks later_______________________________
Immunoglobulin • 100 mg/kg (maximum 7000 mg) IV ___________________ • 2 gram/kg (maximum of 140 grams) IV____________________________
Azathioprine • 3 mg/kg/d to 5 mg/kg/d single dose given at time of transplantation • 1 mg/kg/d to 3 mg/kg/d for maintenance • Dose usually adjusted depending on WBCs
___________________ • Lower doses should be considered in presence of renal dysfunction
Cyclophosphamide • 2 mg/kg/d to 3 mg/kg/d is initial recommended dose, but is rapidly _____________________reduced due to toxicity_________________________________________ Cyclosporine-A Gelatin Capsules & Oral Solution (non-modified) • 15 mg/kg single dose given 4 to 12 hours prior to transplantation
• Usual starting dose in 4-10 mg/kg in bid dosing. Dose is titrated to achieve whole blood levels of 200-300 mg/mL
IV Infusion • 5 mg/kg to 6 mg/kg single dose given 4 to 12 hours prior to
transplantation • Single daily IV dose continued postoperatively until patient can tolerate
_____________________oral formulations______________________________________________ Cyclosporine NOTE: Neoral, Gengral, and Sandimmune are not bioequivalent and Capsules and Oral should not be used interchangeably. Neoral has increased Solution bioavailability, and this should be taken into consideration when (modified) making dosing decisions.
