Leonardo da Vinci (1452-1519) epitomized the Renaissance, living, thinking, and creating art and technology that still characterizes that age of discovery. He typified the free spirit, zest for life, and nature of the ultimate Renaissance man. Indeed, he was an extraordinarily gifted genius who gready advanced knowledge of the arts, such as drawing, painting, sculpting, as well as architecture, warfare tech nology, navigation, and many other critical aspects of human interest. His intense commitment to knowledge did not stop with these fields either. He also advanced anatomy to previously unknown levels. This writing delves into Leonardos contri butions to anatomy and explains how his discoveries subsequently facilitated the practice of surgery.