ABSTRACT
B-mode ultrasonography has been employed since the mid-1980s as a method of measuring the progression of carotid atherosclerosis in clinical trials designed to test a variety of cardiovascular treatment modalities, including lipid-lowering regimens. This chapter will begin with a short historical background describing the rationale for using this imaging technique. This will be followed by a discussion of six trials that have used ultrasonography to test the effects of lipidlowering treatments on carotid atherosclerosis.
