ABSTRACT
The term “bioadhesion” refers to any bond formed between two biological surfaces, or a bond between abiological and asynthetic surface. In the case of bioadhesive drug delivery systems, the term bioadhesion is typically used to describe the adhesion between polymers, ether synthetic,
12.6 Preparation of Bioadhesive Microspheres ..........................................................................265 12.6.1Solvent Evaporation ..............................................................................................265 12.6.2Hot Melt Microencapsulation ...............................................................................265 12.6.3 Solvent Removal ...................................................................................................266 12.6.4 Hydrogel Microspheres .........................................................................................266 12.6.5 Spray Drying .........................................................................................................266 12.6.6Phase Inversion Microencapsulation ....................................................................266 12.6.7Supercritical Fluid Technology.............................................................................266
12.7 Evaluation of the Bioadhesive Microspheres ......................................................................266 12.7.1 Production Yield ................................................................................................... 267 12.7.2 Drug Content and Loading Efciency .................................................................. 267 12.7.3Particle Size Measurement ................................................................................... 267 12.7.4Surface Characterization of the Bioadhesive Microspheres ................................. 267 12.7.5 Determination of Bulk Density ............................................................................ 267 12.7.6 Angle of Repose.................................................................................................... 267 12.7.7 Zeta Potential Study.............................................................................................. 267 12.7.8Swelling Property .................................................................................................268 12.7.9Infrared Absorption Study ....................................................................................268 12.7.10 Measurement of Adhesive Strength/In Vitro Tests ...............................................268
