ABSTRACT
In this book, we have presented the ways that large-scale high-thoughput technologies and computational systems biology have started to revolutionise cancer research and clinical management. We have reviewed in particular how systems biology can help understand the principles of tumorigenesis∗ and tumour progression∗, and we suggest improvements in cancer treatment through better diagnosis, prognosis∗, prediction of response to drugs, identification of new drug targets, and optimisation of therapeutic strategies for killing cancer with drugs. In this last chapter, we briefly discuss alternative approaches for curing cancers, and present a few forthcoming challenges of computational systems biology of cancer.
