ABSTRACT
The biological and biomedical importance of membrane proteins can hardly be overstated. More than 30% of all genes encode membrane proteins and 60% of approved drug targets are membrane proteins. With recent breakthroughs in protein
4.1 Introduction ....................................................................................................95 4.2 Overview of Mechanosensitive Channels .......................................................97 4.3 Literature Reviews of Mechanosensitive Channels of Large Conductance ... 100
4.3.1Overview of Experimental Investigations ........................................ 100 4.3.2Reviews of Analytical Modeling Efforts .......................................... 101 4.3.3 Previous Numerical Approaches ...................................................... 102
4.4 Continuum-Based Approaches: Model and Methods for Studying Mechanosensitive Channels of Large Conductance ..................................... 105
4.5Gating Mechanisms of Mechanosensitive Channels of Large Conductance and Insights for Mechanotransduction ................................... 106 4.5.1 Effect of Different Loading Modes .................................................. 106
4.5.1.1 Gating Behaviors upon Equibiaxial Tension ..................... 106 4.5.1.2Gating Behaviors on Bending ............................................ 109 4.5.1.3 Insights into Loading Modes versus Mechanotransduction ...109
