ABSTRACT
RNA sequences would be information. Proteins and approximately
1-1.5% of DNA protein-coding sequences (CDSs) in the human
genome correspond to the system. Recently, as part of its informa-
tion, hundreds of microRNA (miRNA) genes have been identified by
high-throughput methods, which were derived from approximately
99% information of human genome sequences. Although aberrant
miRNA gene expression causes various cancers, miRNA mimic and
anti-miRNA oligonucleotides (AMOs) have been applied for the
therapy of human cancer models as effective agents. It is suggested
that cancer may be an RNA gene disease that would be caused
by RNA gene information errors on the system frozen. On the
contrary, the therapeutic experiment with administration of the
viral miRNA mimic against pseudo-HIV-1 target using spuma vector
nanoparticles (∼100 nm) has been performed and it has been shown that the miRNA mimic was effective to decrease the target
virus in vivo, suggesting that the nanoparticles can transmit miRNA
information. Before the results, we hypothesized in the RNA wave
2000 model that miRNA would be a mobile genetic element and
miRNA could tune both transcription and translation. Recently,
nanoparticels (20-100 nm) as chemical substances and nanoRNA
(∼10 nucleotides [nt] long) information by locked nucleic acid (LNA) have been reported as safer administration; therefore, there
is some possibility that the RNA information gene (Rig) could
directly be injected intravenously or orally for cancer treatment
without vectors. Taking together the results from these papers about
miRNA research, we can set criteria for RNA information gene
diseases (RigDs) upon RNA waves-“The disease is a system error
that can be retuned by correct miRNA information.” Thus, on the
basis of the criteria, RigDs should be treated with miRNA agents
as information technology (IT)-based therapies (ITBTs), such as
nanoRNA and AMOs into nanoparticles of corporate chemotherapy
and gene therapy as system-based therapy.
