ABSTRACT

Twin-twin transfusion syndrome (TTTS) is one of the most challenging complications of the monochorionic twinning process. Characterized by high perinatal mortality and morbidity rates, TTTS has stimulated intense research interest globally over the past two decades. The advent of obstetric ultrasound has enabled the accurate prenatal identification of TTTS and this detection capability has facilitated potential therapeutic interventions. Additionally, the treatment modalities have been refined as knowledge of the pathophysiology of TTTS has improved. It is evident that TTTS is a complex condition and, as yet, there is no intervention which consistently produces optimal perinatal outcomes.