ABSTRACT
Obesity has been associated with a variety of diseases such as type II diabetes mellitus, arterial hypertension, and atherosclerosis. Evidences have shown that exercise training promotes beneficial effects on these disorders, but the underlying mechanisms are not fully understood. The aim of this study was to investigate whether physical pre-conditioning prevents the deleterious effect of high caloric diet in vascular reactivity of rat aortic and mesenteric rings. High caloric diet increased triglycerides concentration (sedentary diet (SDD): 216 ± 25 mg/dl) and exercise training restored to the baseline value (trained diet (TRD): 89 ± 9 mg/dl). Physical pre-conditioning significantly reduced insulin levels in both groups (trained control (TR): 0.54 ± 0.1 and TRD: 1.24 ± 0.3 ng/ml) as compared to sedentary animals (sedentary control (SD): 0.87 ± 0.1 and SDD: 2.57 ± 0.3 ng/ml). On the other hand, glucose concentration was slightly increased by high caloric diet, and RT did not modify this parameter (SD: 126 ± 6; TR: 140 ± 8; SDD: 156 ± 8 and TRD 153 ± 9 mg/dl). Neither high caloric diet nor RT modified NOx-levels (SD: 27 ± 4; TR: 28 ± 6; SDD: 27 ± 3 and TRD: 30 ± 2 μM).
