ABSTRACT
Introduction A main goal of evolutionary genetics is to document naturally occurring variation and to reconcile observed patterns with population history and demography, tness consequences, and selection regimes at genes of interest [1], [2]. Study of the adaptive maintenance of molecular variation historically has followed one of two approaches, elucidation of the functional components of molecular adaptations at the biochemical level, or description of the historical footprints of selection acting on sequence variants [3]. An important objective in modern studies of molecular adaptation is to bridge the two approaches by means of comprehensive research integrating functional data with information on patterns of variation that implicate past selection [4] (see also [3], [5]–[7]).
