ABSTRACT
Introduction ....................................................................................................................................220 Human Cancer ..........................................................................................................................220 Development of Experimental Oncology and Other Advances ................................................ 221 Animal Models in Human Cancer Studies ............................................................................... 221
Animal Species Used to Model Human Cancer ............................................................................ 223 Mice .......................................................................................................................................... 223
Outbred Mice .......................................................................................................................228 Inbred Mice .......................................................................................................................... 229 Immunodeficient Mice ......................................................................................................... 229 Mutagenized Mice ................................................................................................................230 Genetically Engineered Mice ............................................................................................... 231
Rats ............................................................................................................................................ 233 Outbred Rats .........................................................................................................................234 Inbred Rats ...........................................................................................................................234 Immunodeficient Rats ..........................................................................................................234 Mutagenized Rats .................................................................................................................234 Genetically Engineered Rats ................................................................................................ 235
Other Rodents ........................................................................................................................... 235 Rabbits ....................................................................................................................................... 235 Companion Animals ................................................................................................................. 236 Farm Animals ........................................................................................................................... 237 Exotic and Wild Animals .......................................................................................................... 238 Nonhuman Primates ................................................................................................................. 239 Fish Species ............................................................................................................................... 239 Invertebrates ..............................................................................................................................240
