ABSTRACT

What do we mean by “collective cell migration”? The scope of this phenomenon includes different forms of motion of groups of cells moving together. In this review, we focus only on eukaryotic cells that belong to a multicellular organism, thereby not treating the collective motion of bacteria. Most cells of a multicellular adult organism are rather stationary, but situations of collective migration of cells arise during the normal embryonic development process [1-3] and the physiological responses during wound healing or immune response. It also plays an important role during pathologies such as cancer metastasis [4]. During these processes, cells have to be both motile and have a certain degree of adhesion to one another [5], so that the collectivity of the migration is maintained.