ABSTRACT
Background e toxicology of nano-sized (diameter < 100 nm) particles is a topic of current interest because there have been rapid advances in the synthesis of novel nanomaterials for research, consumer, and industrial applications. Recent reviews have discussed nanoparticle health eects [1,2]. e growing evidence of adverse health eects from exposure to incidentally produced ultrane particles from combustion and atmospheric processes motivates concern about manufactured nanomaterials. ere is epidemiological evidence for cardiovascular eects of ambient ultrane particulate matter (PM) [3]. Indications that inhaled particles can translocate to the other organs [4] suggest a link between nanoparticles and neurodegenerative diseases [5] and other systemic pathologies. Monitoring human exposure to engineered nanoparticles (from air, water, food, consumer products,
and soil), determining the rate of particle uptake by humans and food chain organisms, and measuring the resulting nanoparticle concentrations in target organs are major challenges for nanoparticle toxicology studies [6].
