ABSTRACT
Epidemiology APAP 1. >100,000 analgesic overdoses (ODs)/year, >200 deaths, 46% due to APAP. 2. APAP OD hospitalizations > all other OD hospitalizations. 3. APAP has replaced ASA as the analgesic-antipyretic of choice, especially for children
2° safety prole, NAC antidote, ASA toxicity, and potential to precipitate Reye’s Syn. 4. APAP toxicity risk factors: ↓ hepatic glutathione stores in chronic alcoholics and
malnourished; P450 induction 2° isoniazid (INH) and anticonvulsants.
