ABSTRACT

The most common forms of cancer in the Western world include lung, colorectal, prostate, and breast cancer, and it is well established that modiable risk factors play a role in the development of these forms of cancer (World Health Organization 2008; World Cancer Research Fund/American Institute for Cancer Research 2007). Interest in the role of diet in the prevention of cancer stems from ecological observations of the increase in cancer incidence and mortality over time within a country, differences of prevalence of subtypes of cancer between countries, and changes in cancer risk with migration. For example, a temporal association is shown between the dramatic rise in

14.1 Introduction .......................................................................................................................... 281 14.2 n-3 PUFA .............................................................................................................................. 282

14.2.1 FA Classication ....................................................................................................... 282 14.2.2 Dietary Sources and Intake ...................................................................................... 282 14.2.3 FA Metabolism ......................................................................................................... 282

14.3 Inammation and Cancer .....................................................................................................284 14.4 Proposed Anti-Inammatory and Anticancer Mechanisms of n-3 PUFA ...........................284