ABSTRACT
Ovarian cancer is the fth most frequently occurring cancer in North American women, and is the leading cause of gynecological cancer death in this population. Although the etiology of ovarian cancer remains unclear, certain risk factors have been implicated for this disease. These include hereditary factors such as mutations in the tumor suppressor proteins BRCA1 or BRCA2, reproductive factors such as
12.1 Introduction .................................................................................................. 261 12.2 Biology of Ovarian Cancer ........................................................................... 262
12.2.1 Origins of Ovarian Cancer ............................................................... 263 12.2.2 Modeling Human Ovarian Cancer in Rodents: Xenografted
and Syngeneic Transplants ............................................................... 263 12.2.3 Modeling Human Ovarian Cancer in Transgenic Mice ...................264 12.2.4 Nonmammalian Models of Ovarian Cancer ....................................265
