ABSTRACT
Correspondence Address: Eiichi Araki, M.D., Ph.D., Department of Metabolic Medicine, Kumamoto University School of Medicine, 1-1-1, Honjo, Kumamoto, 8608556, Japan. Tel: +81-96-366-8397; E-mail: earaki@kaiju.medic.kumamoto-u.ac.jp
SUMMARY
The IRS (insulin receptor substrate) family, including IRS-1 and IRS-2, play an important role in the intracellular insulin signal transduction. After phosphorylation by the insulin receptor, IRS proteins bind to the several intracellular proteins that contain src homology 2 (SH2) domains, such as the regulatory subunit of phosphatidylinositol 3 kinase (PI 3kinase) and the adapter molecule Grb-2, and mediate various insulin signals downstream.
