ABSTRACT

By way of these two types of interactions, cells can communicate bidirectionally with each other and respond to changes in the extracellular environment (Miranti and Brugge 2002). The process of adhesion regulates cell shape and biomechanics and is required for a variety of other cellular processes, including proliferation, differentiation, migration, invasion, embryogenesis, wound healing, and tissue remodeling as well as maintenance of three-dimensional multicellular tissues and organs (Kim 2011). Therefore, control of cellular adhesion has important technological applications in the design and use of devices for stem cell isolation or scaffolds used in tissue repair.