ABSTRACT
This is the fourth edition of this work and, as with past editions, it is intended to provide a comprehensive review of reagents used for the chemical modication of proteins. There is a considerable history of the chemical modication of proteins, which is largely beyond the scope of the present volume. There will be occasional mention of the older literature in the current work when necessary but the serious reader is directed to several excellent reviews.1-4 While the technology may be dated, the data are useful and can be very instructive. The three-volume work by J. Leyden Webb5 is of considerable value in the current discipline of systems biology6 as he discusses early work that was performed in whole animals and selected tissues. A minimum amount of effort is expended on the functional consequences of modication except when such would provide insight into the chemistry of reaction.
