ABSTRACT
Introduction ............................................................................................................ 145 Neurosteroids in Traumatic Brain Injury (TBI): Overview of Preclinical Studies ... 146 Neurosteroids and TBI: Overview of Clinical Studies .......................................... 147
Clinical Trials .................................................................................................... 147 Biomarker Studies ............................................................................................. 148
Neurosteroids as Biomarker Candidates: Pilot Investigations in Iraq and Afghanistan Era Veterans with a History of Blast-Related TBI ...................... 149 Neurosteroids as Therapeutics: Pilot Proof-of-Concept Controlled Trial in Iraq and Afghanistan Era Veterans with a History of Mild TBI ........................ 151 Summary and Future Directions ............................................................................ 154 Acknowledgments .................................................................................................. 155 Disclosures ............................................................................................................. 156 References .............................................................................................................. 156
will provide an overview of preclinical data supporting a role for neurosteroids in TBI, followed by a summary of clinical studies to date involving neurosteroids and TBI. Next, the development of neurosteroids as both biomarker candidates and treatment interventions will be discussed. Initial data examining neurosteroid alterations in Iraq and Afghanistan era veterans with a history of blast-related TBI will be presented, and a theoretical framework for the translation of these biomarker efforts to clinical endeavors will be provided. Results from a pilot proof-of-concept neurosteroid intervention in mild TBI will be presented as an example of a potential biomarker-informed translational model, followed by a synopsis of this area and discussion of future directions.
