Glycosylation of Phenolic Acceptors Using Benzoylated Glycosyl Trichloroacetimidate Donors

Phenolic O-glycosides are common in nature, often possessing signicant biological properties.1 Their isolation from natural sources in sufcient quantities and purities is, however, often challenging. Thus, preparative approaches based on chemical synthesis methods are needed. In fact, the rst reported chemical glycosylation reaction was the glycosylation of potassium phenolate with 2,3,4,6-tetra-O-acetyl-α-dglucopyranosyl chloride.2