ABSTRACT
The location of PTEN on chromosome 10q23 is important, because this is a genomic region that suffers loss of heterozygosity in many human cancers (Cantley and Neel, 1999). Although early genetic studies did not find any genetic heterogeneity among BRRS and CS patients, subsequent studies have suggested rare locus heterogeneity that accounts for the majority of patients for whom genetic mutations were not initially described (Zhou et al., 2003b).
