chapter
Cocaine
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Due to inhibition of CYP2D6mediated metabolism of MDMA

Avoid concurrent use

MDMA DRUG DEPENDENCE THERAPIES – BUSPIRONE

Markedly ≠ risk of serotonin syndrome

Buspirone is a direct stimulant of 5-HT receptors (5-HT1A)

MDMA H2 RECEPTOR BLOCKERS – CIMETIDINE

≠ plasma concentrations of MDMA, with risk of toxic effects

Due to inhibition of CYP2D6mediated metabolism of MDMA

Avoid concurrent use

COCAINE

Blocks sodium channels. Produces euphoria, mood elevation, energy, tremors, chest pain, agitation, paranoia and convulsions

It ≠ heart rate, BP and cardiac output, as well as enhancing platelet aggregation COCAINE ANTIDEPRESSANTS

COCAINE MAOIs Hypertensive crisis Due to Ø metabolism of vasoactive amines

Avoid concurrent use