ABSTRACT
Due to inhibition of CYP2D6mediated metabolism of MDMA
Avoid concurrent use
MDMA DRUG DEPENDENCE THERAPIES – BUSPIRONE
Markedly ≠ risk of serotonin syndrome
Buspirone is a direct stimulant of 5-HT receptors (5-HT1A)
MDMA H2 RECEPTOR BLOCKERS – CIMETIDINE
≠ plasma concentrations of MDMA, with risk of toxic effects
Due to inhibition of CYP2D6mediated metabolism of MDMA
Avoid concurrent use
COCAINE
Blocks sodium channels. Produces euphoria, mood elevation, energy, tremors, chest pain, agitation, paranoia and convulsions
It ≠ heart rate, BP and cardiac output, as well as enhancing platelet aggregation COCAINE ANTIDEPRESSANTS
COCAINE MAOIs Hypertensive crisis Due to Ø metabolism of vasoactive amines
Avoid concurrent use
