ABSTRACT
NEFOPAM 1. ANTIARRHYTHMICS – disopyramide, propafenone 2. ANTIDEPRESSANTS – TCAs 3. ANTIEMETICS – cyclizine 4. ANTIHISTAMINES – chlorphenamine, cyproheptadine, hydroxyzine 5. ANTIMUSCARINICS – atropine, benzatropine, cyclopentolate, dicycloverine, flavoxate, homatropine, hyoscine, orphenadrine, oxybutynin, procyclidine, propantheline, tolterodine, trihexyphenidyl or tropicamide. 6. ANTIPARKINSON’S DRUGS – dopaminergics 7. ANTIPSYCHOTICS – phenothiazines, clozapine, pimozide 8. MUSCLE RELAXANTS – baclofen 9. NITRATES – isosorbide dinitrate
≠ risk of antimuscarinic sideeffects. NB å efficacy of sublingual nitrate tablets
Additive effect; both drugs cause antimuscarinic side-effects. Antimuscarinic effects å saliva production, which å dissolution of the tablet
Warn patients of this additive effect. Consider using sublingual nitrate spray
