ABSTRACT
References 427
Although Alzheimer (1907) highlighted the two key histological lesions, amyloid plaques and neurofibrillary tangles (NFTs) more than 100 years ago, recent developments in molecular biology, molecular genetics, immunohistochemistry, image analysis and protein chemistry have transformed our understanding of the pathogenesis of Alzheimer’s disease (AD). For practising neuropathologists, immunohistochemistry in particular has become an essential part of the diagnostic armoury to complement the neurohistology of the common neurodegenerative conditions.
