ABSTRACT
Poor water solubility of many chemical entities constitutes a major challenge in their formulation development as drug delivery systems. The drugs with low solubility lead to low oral bioavailability and erratic absorption. Pharmaceutical industries are constantly seeking new strategies in order to obtain formulation methods to overcome poor solubility and bioavailability as well as to achieve site-specic drug delivery. Numerous nanosystems have been investigated for the colloidal dispersion of poorly water-soluble drugs, including liposomes, nanoparticles, polymeric micelles, and dendrimers. Nanosuspensions have revealed their potential to solve the problem associated with the delivery of poorly water-and lipid-soluble drugs. It enhances the absorption and bioavailability and helps to reduce the dose of conventional oral dosage forms (Kumar and Krishna, 2011).
