ABSTRACT
Introduction ................................................................................................................................. 196 Coating Technology in Release Rate Control ..................................................................... 196 Sustained Release ProŠle ...................................................................................................... 197 Pulsatile Release ProŠle ......................................................................................................... 197
Release Rate Control Principles ............................................................................................... 199 Diffusion .................................................................................................................................. 199
Diffusivity Control Theory ............................................................................................... 202 Porous Perspective ................................................................................................................. 203
Nonporous Perspective .................................................................................................... 210 Partition/Solubility Oriented .......................................................................................... 215 Equilibrium Condition of Partition ................................................................................. 217 Partition of Protein in Aqueous Two-Phase Systems ................................................... 217 Partition of Protein in Hydrogel Membrane ................................................................. 218 Excess Function and Activity CoefŠcient (for Nonelectrolytes) ................................. 219 Polymer Solution ............................................................................................................... 226 Modeling of Charged Solute Partitioning in Hydrogel ...............................................230
