ABSTRACT
In response to emerging concerns that environmental chemicals may have adverse effects on human health by altering the function of the endocrine system (1), the Food Quality Protection Act and subsequent amendments to the Safe Drinking Water Act and Federal Food, Drug and Cosmetic Act (FFDCA) mandated that the U.S. EPA
develop a screening program using appropriate validated test systems and other scientifically relevant information, to determine whether certain substances may have an effect in humans that is similar to an effect produced by a naturally occurring estrogen, or other such endocrine effect as the Administrator may designate [21 U.S.C. 346a(p)] (2,3).
