chapter  2
22 Pages

Investigation Systems to Study the Biological Effects of Weak Physiological Electric Fields

Introduction ......................................................................................................... 18 Dosimetry ............................................................................................................ 18

Determination of Eo ....................................................................................... 19 Cell Shape and Orientation ............................................................................ 20

Ellipsoidal Cells: General Considerations ................................................. 20 Ellipsoidal Cells: Numerical Modeling ..................................................... 22 Ellipsoidal Cells: Analytical Modeling ..................................................... 25 Ellipsoidal Cells: Poorly Conducting Media ............................................. 26 Cells of Arbitrary Shape ............................................................................ 26

Dense Cell Systems ........................................................................................ 28 Pulsed Fields .................................................................................................. 29

Confounding Factors ........................................................................................... 29 Electrical ........................................................................................................ 30 Thermal .......................................................................................................... 30 Chemical ........................................................................................................ 31 Mechanical ..................................................................................................... 32 Other Potential Confounders .......................................................................... 33

Experimental Design ........................................................................................... 34 Conclusions ......................................................................................................... 36 References ........................................................................................................... 36

This volume features the results of experiments on cell systems exposed to electric šelds (Chapters 3-12). Such experiments require a broad set of skills for their successful execution and interpretation because of their cross-disciplinary nature. The independent variable, the electric šeld or a related parameter to which the cell is exposed, must be well characterized. A variety of confounding factors that can reduce or even completely eliminate the action of the šeld must be identišed and eliminated.