chapter  11
46 Pages

Supramolecular Complex Design and Function for Photodynamic Therapy and Solar Energy Conversion via Hydrogen Production: Common Requirements for Molecular Architectures for Varied Light-Activated Processes

Introduction ............................................................................................................256 Scope and Limitations ....................................................................................... 257 Supramolecular Devices and Their Components .............................................. 257 Light Absorption and Electronic Excited States ............................................... 258 Redox Chemistry of Supramolecular Metal Complexes ................................... 261

PDT by Supramolecular Complexes ...................................................................... 263 DNA as a Target for PDT .................................................................................. 263 Development of PDT Drugs .............................................................................. 263 Ru and Os Polyazine Complexes as Light Absorbers for PDT .........................264 Supramolecular Complexes Coupling Ru(II) Polyazine Light Absorbers to Rh(III) Metal Centers for PDT ..........................................................................264

Supramolecular complexes are ideally suited for the development of novel materials to perform complex functions. The application of supramolecular complexes in this forum has been limited by the synthetic ability to construct complex assemblies and a detailed understanding of the perturbations of the individual component’s properties upon incorporation into the supramolecular assembly. The synthetic methodology to prepare supramolecular complexes of signiˆcant structural diversity has been expanding rapidly in the last decade. This has led to fundamental studies of the perturbation of subunit properties upon incorporation into supramolecular assemblies and is providing a database of properties that has allowed preliminary systems to be designed to perform complicated functions. The structural arrangement of subunits within the assemblies as well as the electronic coupling of subunits is critical