ABSTRACT
Osteoarthritis (OA), a degenerative disease of the joint, is loosely divided into di›erent groups based on the joints involved. ‘e form which includes multiple joints, hands, knees, hips, and spine, is considered to be hereditary; the form which includes only peripheral joints or a single joint such as knee or hip is not considered to be hereditary [1-4]. OA can be primary, purely degenerative, or secondary, typically to trauma, rheumatoid arthritis, or to infection [3]. In this chapter, we will concentrate on degenerative joint disease. Since many of the histopathological changes and other disease features in OA are similar in di›erent joints; for the sake of simplicity, we will concentrate on the knee joint.
