ABSTRACT
Inferior petrosal sinus sampling (IPSS) is used in the differential diagnosis of Cushing’s disease and when there is a strong clinical suspicion of a hyperfunctioning pituitary adenoma and non-invasive methods have failed to establish the diagnosis. These adenomas may secrete prolactin, adrenocorticotropin (ACTH), growth hormone (GH), or thyrotropin secreting hormone (TSH). The initial application of IPSS was the evaluation of patients with Cushing’s syndrome. This remains the main indication for its use.
