chapter  8
38 Pages

Chromatographic Hydrophobicity Index (CHI)

It is generally accepted that any pharmacological process occurs in three conceptual steps: penetration, binding, and activation [1]. Hence, to be efˆcient, it is crucial that a new molecule with potential pharmacological activity possesses adequate abilities to gain access to the biological system, to bind to the biological target and, ˆnally, to achieve a biological response from the formed adduct with an observable effect.