ABSTRACT
References ...................................................................................................................................... 195
Systems biology nowadays invades all areas of biomedical research and seems to provide a promising avenue for the understanding and diagnosis of different diseases and even for šnding a cure for them (Wolkenhauer et al., 2009). Although the concept of systems biology was founded over 60 years ago (Weiner, 1948), its breakthrough came in the last decade along with the sequencing of the šrst whole genomes. This was the starting point for comprehensive studies of particular molecule types in one organism. The study of these omes, such as genomes, transcriptomes, proteomes, or metabolomes, led to the formation of research šelds of their own, summarized under the term omics. In parallel, the availability of comprehensive genome data together with high-throughput measurement methods revived the idea of system biological approaches to study biomedical problems (Kitano, 2002).
